Stara Veronika, Mach Mojmir, Ujhazy Eduard, Liptak Boris, Gasparova Zdenka
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovak Republic.
Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.
Interdiscip Toxicol. 2018 Oct;11(3):217-220. doi: 10.2478/intox-2018-0020. Epub 2019 Oct 18.
Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer΄s disease and dementia.
抚摸是一种经验形式，根据其实施时的产后年龄阶段，可导致生理变化。有大量证据表明新生儿抚摸具有积极作用，但关于成年大鼠抚摸的研究较少。行为改变和记忆缺陷存在于类似痴呆的病症中。在本研究中，我们测试了对年轻成年大鼠持续6周的抚摸是否能逆转由三甲基锡（TMT）（7.5毫克/千克，腹腔注射）诱导的记忆损伤。在莫里斯水迷宫中对大鼠进行测试发现，TMT有显著影响，抚摸也有显著影响。我们观察到，无论是健康、未退化的大鼠还是退化的大鼠，空间记忆都有改善，表现为登上平台的潜伏期缩短。在我们的论文中，我们报告了抚摸对空间记忆的有益作用，这与已发表的关于认知疗法和训练对早期阿尔茨海默病和痴呆患者有益作用的研究结果一致。
