From the Division of Hospital Medicine, Department of Pediatrics.
Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Pediatr Infect Dis J. 2019 Dec;38(12):1224-1227. doi: 10.1097/INF.0000000000002473.
We performed a prospective cohort study to investigate oseltamivir administration in critically ill children. We found that enteric tube administration of oseltamivir resulted in lower concentrations of its active metabolite compared with oral delivery. These findings could have significant clinical implications, and more studies are required to better understand the effects of administration route on potential lower systemic metabolite exposure.
我们进行了一项前瞻性队列研究，调查了重症儿童中奥司他韦的给药情况。我们发现，与口服给药相比，奥司他韦的肠内管给药导致其活性代谢物的浓度降低。这些发现可能具有重要的临床意义，需要更多的研究来更好地了解给药途径对潜在全身代谢物暴露降低的影响。
