Department of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008, Hunan, PR China.
Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008, Hunan, PR China.
Biomed Pharmacother. 2020 Jan;121:109651. doi: 10.1016/j.biopha.2019.109651. Epub 2019 Nov 15.
SH2B1 is well-known as an adaptor protein, and deletion of SH2B1 results in severe obesity and both leptin and insulin resistance. Some studies have revealed that SH2B1 is involved in the progression of lung cancer, esophageal cancer, gastric cancer, oropharyngeal cancer, and so on. Biological function experiments have proven that SH2B1 can regulate cellular morphology, motility and adhesion by modifying the actin cytoskeletal reorganization, and it can promote cell mitogenesis, transformation, survival and differentiation via different signal pathways by enhancing the kinase activity of several receptor tyrosine kinases. In addition, SH2B1 is an obesity-related gene, and epidemiological surveys suggest a complex relationship between obesity and cancer. Therefore, what is the relationship between SH2B1 and cancer? Herein, we attempt to provide a mini overview of the roles of SH2B1 in cancer.
SH2B1 是一种众所周知的衔接蛋白，其缺失会导致严重肥胖以及瘦素和胰岛素抵抗。一些研究表明，SH2B1 参与了肺癌、食管癌、胃癌、口咽癌等多种癌症的进展。生物学功能实验已经证明，SH2B1 可以通过调节肌动蛋白细胞骨架的重排来调节细胞形态、运动和黏附，并且可以通过增强几种受体酪氨酸激酶的激酶活性，通过不同的信号通路促进细胞有丝分裂、转化、存活和分化。此外，SH2B1 是一种与肥胖相关的基因，流行病学调查表明肥胖与癌症之间存在复杂的关系。那么，SH2B1 与癌症之间存在什么关系呢？在这里，我们试图对 SH2B1 在癌症中的作用提供一个简要的概述。
