Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, Düsternbrooker Weg 17-19, D-24105 Kiel, Germany.
Division of Endocrinology, Diabetology and Clinical Nutrition, Department of Internal Medicine 1, University Hospital Schleswig-Holstein, Campus Kiel, University of Kiel, Düsternbrooker Weg 17-19, D-24105 Kiel, Germany.
Nutrients. 2019 Nov 14;11(11):2759. doi: 10.3390/nu11112759.
Brain gray (GM) and white matter (WM) are associated with resting energy expenditure (REE). The impact of weight loss on GM and WM masses, as well as on their associations with REE and the ratio between body and brain metabolism, i.e., encephalic measure (EM)), are unknown. Longitudinal data of 69 female Caucasian subjects (age range 19-69 years) with detailed information on fat mass (FM), fat free mas (FFM), GM, WM and REE. Mean weight loss was 14.5 ± 11.9 kg with changes in FM (-12.9 ± 9.8 kg), FFM (-1.7 ± 4.8 kg) and REE (-159 ± 191 kcal/24 h) (all < 0.05). With weight loss, there were no changes in GM and WM. Before and after weight loss, FFM was the main determinant of REE ( = 0.483 and 0.413; < 0.05). After weight loss, GM added to the variances in REE (3.6%), REE (6.1%) and the REE on FFM residuals (6.6%). In addition, before and after weight loss GM explained 25.0% and 10.0% of the variances in EM ( < 0.05). Weight loss had no effect on volumes of GM and WM. After weight loss, both, GM added to the variances of REE, REE on FFM residuals and EM.
脑灰质 (GM) 和脑白质 (WM) 与静息能量消耗 (REE) 有关。体重减轻对 GM 和 WM 质量的影响，以及它们与 REE 和身体与大脑代谢比率（即脑测量值，EM）的关系尚不清楚。对 69 名女性白种人受试者的纵向数据进行了分析，这些受试者有详细的脂肪量 (FM)、无脂肪质量 (FFM)、GM、WM 和 REE 信息。平均体重减轻 14.5 ± 11.9 公斤，FM（-12.9 ± 9.8 公斤）、FFM（-1.7 ± 4.8 公斤）和 REE（-159 ± 191 千卡/24 小时）均发生变化（均<0.05）。体重减轻后 GM 和 WM 没有变化。在体重减轻之前和之后，FFM 是 REE 的主要决定因素（=0.483 和 0.413；<0.05）。体重减轻后，GM 增加了 REE（3.6%）、REE（6.1%）和 FFM 残差的 REE（6.6%）的方差。此外，在体重减轻之前和之后，GM 分别解释了 EM 方差的 25.0%和 10.0%（<0.05）。体重减轻对 GM 和 WM 的体积没有影响。体重减轻后，GM 增加了 REE、FFM 残差的 REE 和 EM 的方差。
