晚期卵巢癌患者恶性肠梗阻的预后CT表现。
Prognostic CT findings of malignant bowel obstruction in patients with advanced ovarian cancer.
作者信息
Miccò Maura, Sbarra Martina, Gui Benedetta, Bianco Nicola Carlo, Rodolfino Elena, Manfredi Riccardo
机构信息
Radiologia Diagnostica e Interventistica Generale, Area Diagnostica per Immagini, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Istituto di Radiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
Tumori. 2020 Apr;106(2):149-154. doi: 10.1177/0300891619886657. Epub 2019 Nov 18.
OBJECTIVE
To evaluate computed tomography (CT) findings able to predict outcome in patients with ovarian cancer (OC) and concomitant bowel occlusion.
METHODS
This institutional review board-approved retrospective study included 31 patients with OC and clinical evidence of bowel occlusion who underwent CT at presentation between February 2013 and June 2015. Two radiologists recorded various qualitative CT features. Correlations between CT and survival data were made with Mann-Whitney test, Wilcoxon test, and χ test, as appropriate. Receiver operating characteristic curves were generated for statistically significant CT findings using logistic regression model.
RESULTS
Two of 31 patients (6.5%) were alive at the end of this study; 29 patients (93.5%) died of disease. Median overall survival was 90 days. CT features associated with short life expectancy were bowel mural thinning (=0.03), mesenteric tumor deposits (=0.009), mesenteric infiltration (=0.02), and ascites (=0.04). Area under the curve was 0.728 (=0.03) for mesenteric tumor deposits in predicting malignant bowel obstruction.
CONCLUSIONS
Accurate interpretation of CT features may guide decisions in care of women with OC and bowel obstruction.
目的
评估计算机断层扫描（CT）表现能否预测卵巢癌（OC）合并肠梗阻患者的预后。
方法
这项经机构审查委员会批准的回顾性研究纳入了31例患有OC且有肠梗阻临床证据的患者，这些患者于2013年2月至2015年6月就诊时接受了CT检查。两名放射科医生记录了各种定性CT特征。根据情况，使用曼-惠特尼检验、威尔科克森检验和χ检验对CT与生存数据之间的相关性进行分析。使用逻辑回归模型为具有统计学意义的CT表现生成受试者操作特征曲线。
结果
在本研究结束时，31例患者中有2例（6.5%）存活；29例患者（93.5%）死于疾病。中位总生存期为90天。与预期寿命短相关的CT特征包括肠壁变薄（P=0.03）、肠系膜肿瘤沉积物（P=0.009）、肠系膜浸润（P=0.02）和腹水（P=0.04）。肠系膜肿瘤沉积物预测恶性肠梗阻的曲线下面积为0.728（P=0.03）。
结论
准确解读CT特征可能有助于指导OC合并肠梗阻女性患者的治疗决策。
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