Radiation Oncology Department, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA.
Neuro-Oncology Department, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 431, Houston, TX 77030, USA.
Hematol Oncol Clin North Am. 2020 Feb;34(1):13-28. doi: 10.1016/j.hoc.2019.08.015. Epub 2019 Oct 28.
The 2016 World Health Organization classification of central nervous system (CNS) tumors underwent significant restructuring and for the first time gliomas are classified according to both molecular and histologic parameters which guides glioma management. Radiation for intermediate-risk meningiomas improves the progression-free survival from historical controls, and studies are ongoing for atypical meningiomas. For brain metastases, use of stereotactic radiosurgery for a higher number of lesions has become clinical practice. Additionally, hippocampal-sparing whole brain radiation shows promise in preserving neuro-cognitive function. This article summarizes the evolving role of radiation therapy in the management of malignant CNS neoplasms.
2016 年世界卫生组织中枢神经系统（CNS）肿瘤分类经历了重大调整，胶质瘤首次根据分子和组织学参数进行分类，这为胶质瘤的治疗提供了指导。对于中危脑膜瘤，放疗可改善无进展生存率，优于历史对照，目前正在对非典型脑膜瘤进行研究。对于脑转移瘤，立体定向放射外科治疗更多的病灶已成为临床实践。此外，海马保护全脑放疗在保护神经认知功能方面显示出良好的前景。本文总结了放射治疗在恶性中枢神经系统肿瘤治疗中的作用的演变。
