小儿癌症。

Pediatric Cancer.

机构信息

Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Francis H. Burr Proton Therapy Center, 30 Fruit Street, Boston, MA 02114, USA.

Francis H. Burr Proton Therapy Center, 30 Fruit Street, Boston, MA 02114, USA; Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

出版信息

Hematol Oncol Clin North Am. 2020 Feb;34(1):143-159. doi: 10.1016/j.hoc.2019.08.021. Epub 2019 Oct 31.

DOI:10.1016/j.hoc.2019.08.021

PMID:31739941

Abstract

In pediatric brain tumors, the intensification of chemotherapy has allowed for a reduction in radiotherapy (RT) volume to an involved field approach, particularly in patients with medulloblastoma. For patients with low-grade gliomas, the trend has remained to delay RT with chemotherapy; however, when RT is used, typically smaller clinical target volume margins are used. For patients with extracranial tumors, intensive chemotherapy to address systemic disease with local control is considered standard. Proton beam therapy shows significant promise in addressing both short-term and long-term toxicities in both central nervous system (CNS) and non-CNS pediatric tumors.

摘要

在儿科脑肿瘤中，化疗的强化使得放疗（RT）体积得以减少，采用受累野方法，尤其是在患有髓母细胞瘤的患者中。对于低级别胶质瘤患者，化疗延迟 RT 的趋势仍然存在；但是，当使用 RT 时，通常会使用更小的临床靶区边缘。对于患有颅外肿瘤的患者，采用强化化疗来控制全身性疾病并实现局部控制被认为是标准治疗方法。质子束疗法在解决中枢神经系统（CNS）和非 CNS 儿科肿瘤的短期和长期毒性方面显示出巨大的潜力。