Servicio de Dermatología y Anatomía Patológica, Hospital Infantil Universitario del Niño Jesús, Madrid, España.
Servicio de Dermatología y Anatomía Patológica, Hospital Infantil Universitario del Niño Jesús, Madrid, España.
Actas Dermosifiliogr (Engl Ed). 2020 Jan 2;111(1):20-25. doi: 10.1016/j.ad.2019.02.010. Epub 2019 Nov 15.
Melanocytic neoplasms with spitzoid morphology (Spitz nevi, atypical Spitz tumors, and spitzoid melanomas) may be benign or malignant. Because the malignant potential of atypical Spitz tumors is uncertain, the proper therapeutic approach has been much debated over the years. Promising new techniques for molecular analysis have enabled better predictions of the biological behavior of these tumors. We review their cytogenetic features and prognosis and also provide an update of the most recent recommendations for management.
具有 Spitz 样形态的黑色素细胞肿瘤（Spitz 痣、非典型 Spitz 肿瘤和 Spitz 样黑色素瘤）可能为良性或恶性。由于非典型 Spitz 肿瘤的恶性潜能不确定，多年来其适当的治疗方法一直存在争议。用于分子分析的有前途的新技术使人们能够更好地预测这些肿瘤的生物学行为。我们回顾了它们的细胞遗传学特征和预后，并提供了最新管理建议的更新。
