一种用于胞质蛋白传递的模块化方法：金属离子诱导的金纳米簇自组装作为一种通用平台。
A modular approach for cytosolic protein delivery: metal ion-induced self-assembly of gold nanoclusters as a general platform.
机构信息
Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China.
出版信息
Nanoscale. 2019 Nov 28;11(46):22237-22242. doi: 10.1039/c9nr07334e.
We developed a versatile and modular method for cytosolic protein delivery through metal ion-induced co-assembly of gold nanoclusters and proteins into supramolecular assemblies. The versatility and high efficiency of this strategy to assemble and deliver various proteins into living cells were demonstrated. Importantly, the activity of proteins was maintained during the delivery. This modular approach provides an exciting and promising new nano-platform for cytosolic protein delivery.
我们开发了一种通过金纳米簇和蛋白质通过金属离子诱导共组装成超分子组装体来进行细胞质蛋白输送的通用且模块化的方法。该策略在将各种蛋白质组装并递送到活细胞中时具有通用性和高效率。重要的是，在输送过程中保持了蛋白质的活性。这种模块化方法为细胞质蛋白输送提供了一个令人兴奋且有前途的新的纳米平台。
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