苯二氮䓬类药物给药对识别情绪面部表情的影响：一项荟萃分析。
Effects of benzodiazepines administration on identification of facial expressions of emotion: a meta-analysis.
机构信息
Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Rua Alfredo Allen, 4200-135, Porto, Portugal.
São João University Hospital Center, Porto, Portugal.
出版信息
Psychopharmacology (Berl). 2020 Jan;237(1):1-9. doi: 10.1007/s00213-019-05393-y. Epub 2019 Nov 18.
RATIONALE
Benzodiazepines, a class of commonly prescribed drugs, were shown to cause cognitive impairments in several domains. However, the effect of benzodiazepines on social cognition is still unclear.
OBJECTIVES
In order to clarify how benzodiazepines administration affects the identification of facial expressions of emotion (FEE), we conducted a meta-analysis of 8 empirical studies (N = 153 benzodiazepines, N = 153 placebo).
RESULTS
Results showed that participants receiving benzodiazepines were less accurate at identifying facial expressions of anger compared with those receiving placebo (M = - 0.52). Regarding the remaining facial expressions, the meta-analysis did not reveal significant differences between the groups.
CONCLUSIONS
We discuss several factors that may explain the differences in the identification of emotions in facial expressions associated with benzodiazepines administration. Additionally, the relevance of assessing the effects of benzodiazepines when used on a long-term basis is addressed.
原理
苯二氮䓬类药物是一类常用的处方药物，已被证明会导致多个认知领域的认知障碍。然而，苯二氮䓬类药物对社会认知的影响仍不清楚。
目的
为了阐明苯二氮䓬类药物的给药如何影响情绪面部表情识别（FEE），我们对 8 项实证研究进行了荟萃分析（N=153 名苯二氮䓬类药物，N=153 名安慰剂）。
结果
结果表明，与接受安慰剂的参与者相比，接受苯二氮䓬类药物的参与者在识别愤怒表情时的准确性较低（M=-0.52）。关于其余的面部表情，组间荟萃分析未显示出显著差异。
结论
我们讨论了几个可能解释与苯二氮䓬类药物给药相关的面部表情情绪识别差异的因素。此外，还讨论了评估长期使用苯二氮䓬类药物的效果的相关性。
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