Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarão, SC, Brazil.
Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
Inflammation. 2020 Feb;43(1):24-31. doi: 10.1007/s10753-019-01124-9.
The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.
脓毒症的病理生理学极其复杂。在此疾病过程中，炎症反应加剧导致氧化应激、线粒体能量动态改变和多器官衰竭。一些研究强调了 NLRP3 炎性小体在脓毒症中的重要作用。该炎性小体是一种精细调节半胱氨酸天冬氨酸蛋白酶-1 激活以及白细胞介素-1β和白细胞介素-18 等强效促炎细胞因子产生和分泌的大型蛋白质复合物。在这篇综述中，我们阐明了证据以了解脓毒症发展与 NLRP3 炎性小体之间的联系，后者是该受体家族中研究最广泛的成员。
