丹麦肾移植受者口腔 HPV 的流行率、型别分布及危险因素。

Prevalence, type distribution and risk factors for oral HPV in Danish renal transplant recipients.

机构信息

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Department of Dermato-Venerology, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark.

出版信息

Oral Dis. 2020 Mar;26(2):484-488. doi: 10.1111/odi.13240. Epub 2019 Dec 12.

DOI:10.1111/odi.13240

PMID:31742827

Abstract

OBJECTIVE

To assess the prevalence and type distribution of oral human papillomavirus (HPV) among renal transplant recipients (RTRs) and healthy controls and to examine risk factors for oral HPV among RTRs.

MATERIALS AND METHODS

During 2016-2017 we recruited 250 RTRs and 250 controls. Oral samples were tested for HPV DNA with INNO-LiPA HPV Genotyping Extra II. All participants answered a questionnaire on lifestyle and sexual behaviour, and characteristics of RTRs were obtained from medical files. We assessed prevalence and type distribution of oral HPV. Using logistic regression, the risk of oral HPV and risk factors for oral HPV among RTRs were estimated as odds ratios (OR) with 95% confidence intervals (CI).

RESULTS

Overall, 30 RTRs (12.1%) and 26 controls (10.4%) were oral HPV positive (OR = 1.14; 95% CI: 0.64-2.05). Female RTRs tended to have a higher oral HPV prevalence than controls (OR = 1.73; 95% CI: 0.63-4.77), while no difference was observed among men. HPV51 was the commonest genotype. Sexual behaviour tended to be associated with oral HPV among RTRs.

CONCLUSIONS

There was no overall difference in oral HPV prevalence between RTRs and controls, but female RTRs tended to have a higher prevalence of oral HPV than controls.

摘要

目的

评估肾移植受者（RTR）和健康对照者口腔人乳头瘤病毒（HPV）的流行率和型别分布，并探讨 RTR 中口腔 HPV 的危险因素。

材料和方法

在 2016 年至 2017 年期间，我们招募了 250 名 RTR 和 250 名对照者。使用 INNO-LiPA HPV Genotyping Extra II 检测口腔样本中的 HPV DNA。所有参与者都回答了一份关于生活方式和性行为的问卷，并从病历中获得了 RTR 特征的信息。我们评估了口腔 HPV 的流行率和型别分布。使用逻辑回归，我们将 RTR 中口腔 HPV 的风险和口腔 HPV 的危险因素估计为比值比（OR）及其 95%置信区间（CI）。

结果

总体而言，30 名 RTR（12.1%）和 26 名对照者（10.4%）口腔 HPV 阳性（OR=1.14；95%CI：0.64-2.05）。女性 RTR 口腔 HPV 流行率高于对照者（OR=1.73；95%CI：0.63-4.77），而男性则无差异。HPV51 是最常见的基因型。性行为在 RTR 中与口腔 HPV 有关。