Division of Physical Therapy Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
College of Nursing-Omaha Division, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
PLoS One. 2019 Nov 19;14(11):e0225446. doi: 10.1371/journal.pone.0225446. eCollection 2019.
The evidence for whether weight loss following longer-term lifestyle interventions results in improved health-related quality of life (HRQoL) is inconclusive. This study examines whether women who lose weight after completing an 18-month web-based lifestyle modification intervention would report a corresponding improvement in HRQoL as measured using the Patient-Reported Outcomes Measurement Information System 29-item profile (PROMIS-29 v1.0).
Data from 216 rural women, ages 40 to 69, with baseline and 18-month PROMIS-29 data were analyzed in this secondary analysis of the Women Weigh-in for Wellness clinical trial. This trial promoted lifestyle modification for initial weight loss (baseline to 6 months) and guided weight loss (6 months to 18 months) using a web-delivery format.
After adjusting for age, number of comorbidities, change in physical activity from baseline, intervention group, and baseline PROMIS-29 scores, change in weight was associated with improved health-related quality of life (HRQoL) in the domains of depression, physical function, pain interference, fatigue, and satisfaction with social role. Logistic regressions, adjusting for the same factors, indicated women with ≥ 10% weight loss were more likely to report lower depression, higher physical function and less pain interference, compared to women who gained weight or lost < 5%.
Among our rural women, a loss in weight from baseline appeared to be associated with overall improvement in multiple PROMIS-29 v 1.0 domains, noting the likelihood of achieving improvement was significantly higher among women who attained ≥ 10% weight loss. These findings may positively influence a woman's adherence to lifestyle modification weight loss and weight maintenance program.
ClinicalTrials.gov NCT01307644.
长期生活方式干预后体重减轻是否能改善健康相关生活质量（HRQoL）的证据尚无定论。本研究旨在探讨完成 18 个月网络生活方式干预后体重减轻的女性，其健康相关生活质量（HRQoL）是否会相应改善，这是通过使用患者报告的结局测量信息系统 29 项简表（PROMIS-29 v1.0）进行测量的。
本研究对 Women Weigh-in for Wellness 临床试验的二次分析中，对 216 名年龄在 40 至 69 岁的农村女性进行了数据分析，这些女性在基线和 18 个月时都有 PROMIS-29 数据。该试验通过网络方式促进初始体重减轻（基线至 6 个月）和指导体重减轻（6 个月至 18 个月）的生活方式改变。
在调整年龄、合并症数量、基线到 6 个月的体力活动变化、干预组和基线 PROMIS-29 评分后，体重变化与以下 HRQoL 领域的改善相关：抑郁、身体机能、疼痛干扰、疲劳和社会角色满意度。在调整了同样因素的逻辑回归分析中，与体重增加或体重减轻<5%的女性相比，体重减轻≥10%的女性更有可能报告较低的抑郁水平、更高的身体机能和较少的疼痛干扰。
在我们的农村女性中，与基线相比的体重减轻似乎与多个 PROMIS-29 v 1.0 领域的整体改善相关，值得注意的是，体重减轻≥10%的女性实现改善的可能性显著更高。这些发现可能会对女性对生活方式改变减肥和体重维持计划的坚持产生积极影响。
ClinicalTrials.gov NCT01307644。
