Penn Comprehensive ALS Center. Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
Muscle Nerve. 2020 Apr;61(4):508-511. doi: 10.1002/mus.26764. Epub 2019 Dec 20.
Validation of biomarkers of upper motor neuron (UMN) impairment in amyotrophic lateral sclerosis (ALS) requires a reliable clinical assessment of UMN findings. The Penn Upper Motor Neuron Score© (PUMNS) is a standardized measure of UMN signs in ALS. Our aims were to evaluate its intra- and inter-rater reliability, and to examine inter-item reliability as a proxy for item relatedness and scale efficiency.
Study procedures were performed during routine clinic visits. We calculated intra and inter-rater reliability using Pearson's correlation coefficient and inter-item reliability using Cronbach's alpha.
PUMNS had high intra and inter-rater reliability. Total and sub-score correlation coefficients were all ≥0.96. The inter-item reliability indicated appropriate item relatedness with reasonable efficiency and sub-score correlation coefficients between 0.68 and 0.85.
PUMNS is a reliable measure of UMN signs in ALS and would be a useful tool in validating imaging and laboratory biomarkers of UMN injury in ALS.
在肌萎缩侧索硬化症（ALS）中验证上运动神经元（UMN）损伤的生物标志物需要对 UMN 发现进行可靠的临床评估。宾夕法尼亚州上运动神经元评分©（PUMNS）是一种用于 ALS 中 UMN 征象的标准化测量方法。我们的目的是评估其内部和内部评分者的可靠性，并检查项目间的可靠性，作为项目相关性和量表效率的替代指标。
研究程序在常规临床就诊期间进行。我们使用 Pearson 相关系数计算内部和内部评分者的可靠性，使用 Cronbach 的 alpha 计算项目间的可靠性。
PUMNS 具有较高的内部和内部评分者可靠性。总分和子评分的相关系数均≥0.96。项目间的可靠性表明项目相关性适当，效率合理，子评分的相关系数在 0.68 到 0.85 之间。
PUMNS 是一种可靠的 ALS 中 UMN 征象的测量方法，它将是验证 ALS 中 UMN 损伤的影像学和实验室生物标志物的有用工具。
