Agache Ioana, Cojanu Catalina, Laculiceanu Alexandru, Rogozea Liliana
Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.
Allergy Asthma Immunol Res. 2020 Jan;12(1):24-41. doi: 10.4168/aair.2020.12.1.24.
Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of disease endotypes to the effectiveness in real-world settings. We discuss here how these barriers can be overcome to facilitate the development of implementation science for allergic diseases and asthma.
对免疫炎症机制在过敏性疾病和哮喘中作用的深入理解，推动了专门针对先天性和适应性免疫反应的生物制剂和小分子药物的研发。从疾病内型的复杂性到实际应用中的有效性，有几个关键点影响着这种分层治疗方法的疗效。我们在此讨论如何克服这些障碍，以促进过敏性疾病和哮喘实施科学的发展。
