Han Ju Hee, Bang Chul Hwan, Han Kyungdo, Ryu Jae Yeon, Lee Jun Young, Park Young Min, Lee Ji Hyun
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Allergy Asthma Immunol Res. 2021 Jul;13(4):638-645. doi: 10.4168/aair.2021.13.4.638.
The spectrum of allergic diseases includes atopic dermatitis (AD), allergic rhinitis (AR), and asthma. To date, the association between allergic diseases and psoriasis has not yet been completely evaluated. This study was conducted to determine the risk of psoriasis in patients with allergic diseases. A health screening database, a sub-dataset of the Korean National Health Insurance Service database, was used. All 9,718,722 subjects who underwent health examination in 2009 at age over 20 were included. Subjects with allergic diseases including AD (n = 35,685), AR (n = 1,362,713), asthma (n = 279,451) and control subjects without all three allergic diseases (n = 8,210,042), without AD (n = 9,683,037), without AR (n = 8,356,009) and without asthma group (n = 9,439,271) were analyzed. The subjects were tracked using their medical records during the 8-year period from 2010 to 2017 to identify those who developed psoriasis. Multivariate Cox regression models were used to assess the risk of psoriasis. The incidence probability of psoriasis was analyzed through the Kaplan-Meier method. The incidence of psoriasis per 1,000 person-years was 9.57, 3.78, and 4.28 in the AD, AR, and asthma groups, respectively. The AD group exhibited a significantly increased risk of developing psoriasis compared to subjects without AD (hazard ratio [HR], 3.18; 95% confidence interval [95% CI], 3.05-3.31; < 0.001) after adjustment for confounding factors. The risk of psoriasis was significantly increased in the AR group compared to subjects without AR (HR, 1.32; 95% CI, 1.31-1.34; < 0.001) and asthma group compared to subjects without asthma (HR, 1.30; 95% CI, 1.27-1.33; < 0.001). Allergic diseases, particularly AD, may be a risk factor for psoriasis.
过敏性疾病谱包括特应性皮炎（AD）、过敏性鼻炎（AR）和哮喘。迄今为止，过敏性疾病与银屑病之间的关联尚未得到全面评估。本研究旨在确定过敏性疾病患者患银屑病的风险。使用了韩国国民健康保险服务数据库的一个子数据集——健康筛查数据库。纳入了2009年所有年龄超过20岁且接受健康检查的9718722名受试者。分析了患有包括AD（n = 35685）、AR（n = 1362713）、哮喘（n = 279451）在内的过敏性疾病的受试者以及没有这三种过敏性疾病的对照受试者（n = 8210042）、没有AD的受试者（n = 9683037）、没有AR的受试者（n = 8356009）和没有哮喘的受试者组（n = 9439271）。在2010年至2017年的8年期间，利用他们的医疗记录对受试者进行跟踪，以确定那些患银屑病的人。使用多变量Cox回归模型评估患银屑病的风险。通过Kaplan-Meier方法分析银屑病的发病概率。AD、AR和哮喘组中银屑病的发病率分别为每1000人年9.57、3.78和4.28。在调整混杂因素后，与没有AD的受试者相比，AD组患银屑病的风险显著增加（风险比[HR]，3.18；95%置信区间[95%CI]，3.05 - 3.31；P < 0.001）。与没有AR的受试者相比，AR组患银屑病的风险显著增加（HR，1.32；95%CI，1.31 - 1.34；P < 0.001），与没有哮喘的受试者相比，哮喘组患银屑病的风险显著增加（HR，1.30；95%CI，1.27 - 1.33；P < 0.001）。过敏性疾病，尤其是AD，可能是银屑病的一个风险因素。
