Department of Oral Physiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50610, Korea.
Department of Orthodontics, School of Dentistry, Pusan National University, Yangsan 50610, Korea.
Int J Mol Sci. 2019 Nov 17;20(22):5778. doi: 10.3390/ijms20225778.
Pentraxin-3 (PTX3) is recognized as a modulator of inflammation and a mediator of tissue repair. In this study, we characterized the role of PTX3 on some biological functions of human dental pulp stem cells (HDPSCs). The expression level of PTX3 significantly increased during osteogenic/odontogenic differentiation of HDPSCs, whereas the knockdown of PTX3 decreased this differentiation. Silencing of PTX3 in HDPSCs inhibited their migration and C-X-C chemokine receptor type 4 (CXCR4) expression. Our present study indicates that PTX3 is involved in osteogenic/odontogenic differentiation and migration of HDPSCs, and may contribute to the therapeutic potential of HDPSCs for regeneration and repair.
五聚素-3（PTX3）被认为是炎症的调节剂和组织修复的介质。在这项研究中，我们研究了 PTX3 在人牙髓干细胞（HDPSCs）的一些生物学功能上的作用。PTX3 的表达水平在 HDPSCs 的成骨/成牙分化过程中显著增加，而 PTX3 的敲低则降低了这种分化。HDPSCs 中 PTX3 的沉默抑制了它们的迁移和 C-X-C 趋化因子受体 4（CXCR4）的表达。本研究表明，PTX3 参与了 HDPSCs 的成骨/成牙分化和迁移，可能有助于 HDPSCs 用于再生和修复的治疗潜力。
