Fornai Francesco, Carrizzo Albino, Forte Maurizio, Ambrosio Mariateresa, Damato Antonio, Ferrucci Michela, Biagioni Francesca, Busceti Carla, Puca Annibale A, Vecchione Carmine
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy ; I.R.C.C.S. Neuromed, Pozzilli, IS Italy.
I.R.C.C.S. Neuromed, Pozzilli, IS Italy.
Immun Ageing. 2016 Aug 24;13(1):25. doi: 10.1186/s12979-016-0080-1. eCollection 2016.
The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate immunity and inflammation. Recent evidence indicates that PTX3 exerts an important role in modulating the cardiovascular system in humans and experimental models. In particular, there are conflicting points concerning the effects of PTX3 in cardiovascular diseases (CVD) since several observations indicate a cardiovascular protective effect of PTX3 while others speculate that the increased plasma levels of PTX3 in subjects with CVD correlate with disease severity and with poor prognosis in elderly patients. In the present review, we discuss the multifaceted effects of PTX3 on the cardiovascular system focusing on its involvement in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis. This may help to explain how the specific modulation of PTX3 such as the use of different dosing, time, and target organs could help to contain different vascular diseases. These opposite actions of PTX3 will be emphasized concerning the modulation of cardiovascular system where potential therapeutic implications of PTX3 in humans are discussed.
急性期蛋白3型五聚体蛋白（PTX3）作为特定病原体的可溶性模式识别受体发挥着不可替代的作用，它是天然免疫和炎症初级局部激活的快速生物标志物。最近的证据表明，PTX3在调节人类和实验模型的心血管系统中发挥着重要作用。特别是，关于PTX3在心血管疾病（CVD）中的作用存在相互矛盾的观点，因为一些观察结果表明PTX3具有心血管保护作用，而另一些则推测CVD患者血浆PTX3水平升高与疾病严重程度以及老年患者的不良预后相关。在本综述中，我们讨论PTX3对心血管系统的多方面影响，重点关注其在动脉粥样硬化、内皮功能、高血压、心肌梗死和血管生成中的作用。这可能有助于解释如何通过对PTX3的特定调节，如使用不同的剂量、时间和靶器官，来控制不同的血管疾病。将着重讨论PTX3在心血管系统调节方面的这些相反作用，并探讨PTX3在人类中的潜在治疗意义。
