Virology Division, ICMR-RMRC; Department of Biotechnology, School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
Virology Division, ICMR-RMRC; Department of Pediatrics, AIIMS, Bhubaneswar, Odisha, India.
Neurol India. 2019 Sep-Oct;67(5):1358-1359. doi: 10.4103/0028-3886.271247.
Acute encephalitis syndrome (AES) is a clinical condition that occurs due to infectious and noninfectious agents- however, viruses are considered to be the dominant pathogen. agents- however, viruses are considered to be the dominant pathogen. In this study, suspected AES cases were enrolled and tested for viral etiology through serology and polymerase chain reaction (PCR)/reverse transcriptase PCR from August 2012-July 2013. During this period, 820 cases were investigated and 96 cases were diagnosed to have a viral etiology whereas 20 patients had IgM antibodies for measles in serum and HSV-1 DNA in cerebrospinal fluid. All 20 of the patients were children below 14 years of age. The median hospital stay was 15 days (IQR: 14.2-17 days) and median GCS score was 7(IQR: 6-8) and were significantly different with patients with co-infections when comapred with patients having HSV-1 infection only. It may be suspected that the measles infection may have a role in the pathogenesis and thus an impact on the prognosis of the AES when present with HSV-1.
急性脑炎综合征（AES）是一种临床病症，由感染性和非感染性病原体引起 - 然而，病毒被认为是主要病原体。在这项研究中，我们招募了疑似 AES 病例，并通过血清学和聚合酶链反应（PCR）/逆转录酶 PCR 检测病毒病因，时间为 2012 年 8 月至 2013 年 7 月。在此期间，我们调查了 820 例病例，其中 96 例被诊断为病毒病因，而 20 例患者血清中麻疹 IgM 抗体和脑脊液 HSV-1 DNA 阳性。所有 20 例患者均为 14 岁以下儿童。中位住院时间为 15 天（IQR：14.2-17 天），中位 GCS 评分为 7（IQR：6-8），与单纯 HSV-1 感染患者相比，与合并感染患者相比差异有统计学意义。当 AES 合并 HSV-1 感染时，麻疹感染可能在发病机制中起作用，从而影响预后。
