Regional Medical Research Centre (ICMR),Bhubaneswar, Odisha,India.
Epidemiol Infect. 2014 Dec;142(12):2514-21. doi: 10.1017/S0950268813003397. Epub 2014 Jan 24.
This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aetiology was identified in 91 (17·2%) cases. Herpes simplex virus (HSV; types I or II) was most common (16·1%), followed by measles (2·6%), Japanese encephalitis virus (1·5%), dengue virus (0·57%), varicella zoster virus (0·38%) and enteroviruses (0·19%). Rash, paresis and cranial nerve palsies were significantly higher (P < 0·05) with viral AES. Case-fatality rates were 10·9% and 6·2% in AES cases with and without viral aetiology, respectively. Simultaneous infection of HSV I and measles was observed in seven cases. This report provides the first evidence on viral aetiology of AES viruses from eastern India showing dominance of HSV that will be useful in informing the public health system.
本研究通过 2011 年 4 月至 2012 年 7 月的医院病例登记，报告了印度东部地区急性脑炎综合征（AES）的临床流行病学特征和病毒病原体。对 526 例 AES 病例的血液和脑脊液样本进行了血清学和/或 PCR 检测。在 91 例（17.2%）病例中确定了病毒病因。单纯疱疹病毒（HSV；I 型或 II 型）最为常见（16.1%），其次是麻疹（2.6%）、日本脑炎病毒（1.5%）、登革热病毒（0.57%）、水痘带状疱疹病毒（0.38%）和肠道病毒（0.19%）。皮疹、瘫痪和颅神经麻痹在病毒性 AES 中明显更高（P < 0.05）。有病毒病因和无病毒病因的 AES 病例的病死率分别为 10.9%和 6.2%。在 7 例病例中观察到 HSV I 和麻疹的同时感染。本报告首次提供了来自印度东部 AES 病毒的病毒病因证据，表明 HSV 的优势地位，这将有助于为公共卫生系统提供信息。
