Department of Dermatology, University of California-Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.
School of Medicine, University of California-Davis, Sacramento, CA, USA.
Am J Clin Dermatol. 2020 Feb;21(1):21-39. doi: 10.1007/s40257-019-00484-0.
Zinc has been used in patients with acne vulgaris for its anti-inflammatory effects; however, it is unclear if zinc supplementation is also beneficial in other inflammatory skin conditions.
The objective of this article was to determine the effect of zinc supplementation on inflammatory dermatologic conditions.
We searched the Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, and Ovid with no time limit up to 29 May, 2019. Trials examining supplementation with zinc in the treatment of inflammatory dermatological conditions (acne vulgaris, atopic dermatitis, diaper dermatitis, hidradenitis suppurativa, psoriasis, and rosacea) in children and adults were selected.
Of 229 articles, 22 met inclusion criteria. Supplementation with zinc was found to be beneficial in ten of 14 studies evaluating its effects on acne vulgaris, one of two studies on atopic dermatitis, one of one study on diaper dermatitis, and three of three studies evaluating its effects on hidradenitis suppurativa. However, the one article found on psoriasis and the one article found on rosacea showed no significant benefit of zinc treatment on disease outcome.
Some preliminary evidence supports the use of zinc in the treatment of acne vulgaris and hidradenitis suppurativa; however, more research is needed with similar methodologies and larger sample sizes in these diseases. Further, zinc may be of some benefit in the treatment plan for atopic dermatitis and diaper dermatitis; however, additional studies should be conducted to further evaluate these potentially positive associations. To date, no evidence is available to suggest that zinc may be of benefit in rosacea and psoriasis; however, limited data are available evaluating the use of zinc in these conditions.
锌因其抗炎作用已被用于治疗寻常痤疮患者；然而，锌补充剂是否对其他炎症性皮肤病也有益尚不清楚。
本文旨在确定锌补充剂对炎症性皮肤病的影响。
我们检索了 Cochrane 对照试验中心注册库、EMBASE、MEDLINE 和 Ovid，检索时间截至 2019 年 5 月 29 日，无时间限制。选择了评估锌补充剂治疗儿童和成人炎症性皮肤病（寻常痤疮、特应性皮炎、尿布皮炎、化脓性汗腺炎、银屑病和酒渣鼻）的临床试验。
在 229 篇文章中，有 22 篇符合纳入标准。在评估锌对寻常痤疮影响的 14 项研究中的 10 项、对特应性皮炎影响的 2 项研究中的 1 项、对尿布皮炎影响的 1 项研究中的 1 项以及评估对化脓性汗腺炎影响的 3 项研究中的 3 项研究中，锌补充被发现是有益的。然而，关于银屑病的一篇文章和关于酒渣鼻的一篇文章显示锌治疗对疾病结局无显著益处。
一些初步证据支持在治疗寻常痤疮和化脓性汗腺炎中使用锌；然而，这些疾病需要更多具有类似方法学和更大样本量的研究。此外，锌可能对特应性皮炎和尿布皮炎的治疗方案有一定益处；然而，应进行更多研究以进一步评估这些潜在的积极关联。迄今为止，尚无证据表明锌可能对酒渣鼻和银屑病有益；然而，评估锌在这些疾病中应用的数据有限。
