Bahramian Ayla, Rahbaran Mona, Bahramian Maria, Bohlouli Sepideh, Katebi Katayoun
Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
J Adv Periodontol Implant Dent. 2023 Sep 30;15(2):128-133. doi: 10.34172/japid.2023.017. eCollection 2023.
Oral lichen planus (OLP) and one of its main presentations, desquamative gingivitis, are common diseases with no definite treatment. Zinc deficiency has a critical role in the pathogenesis of oral mucosal diseases. The current study systematically reviewed the effect of zinc in addition to topical corticosteroids in the treatment of OLP.
English articles in PubMed, Web of Sciences, Embase, and Scopus were searched until August 2022. The differences in symptoms were analyzed, including pain, burning sensation, and lesion sizes in patients with lichen planus receiving zinc supplementation as an adjuvant to corticosteroid treatment.
A total of 148 articles related to the searched keywords were found. Eventually, two clinical trials were selected. The total population of studied individuals included 60 patients. Due to the high heterogeneity between the studies, meta-analysis was not possible. Administering zinc, in addition to corticosteroids, did not improve the symptoms compared to corticosteroid monotherapy.
Considering the limited number of studies and lack of sufficient evidence, it is not currently possible to reach a definite conclusion regarding the effects of zinc on OLP.
口腔扁平苔藓（OLP）及其主要表现之一的剥脱性龈炎是常见疾病，尚无确切的治疗方法。锌缺乏在口腔黏膜疾病的发病机制中起关键作用。本研究系统评价了锌联合局部用糖皮质激素治疗OLP的效果。
检索截至2022年8月PubMed、科学网、Embase和Scopus数据库中的英文文章。分析了接受锌补充剂作为糖皮质激素治疗辅助的扁平苔藓患者的症状差异，包括疼痛、烧灼感和病损大小。
共检索到148篇与检索关键词相关的文章。最终，选取了两项临床试验。研究对象总数为60例患者。由于研究之间的异质性较高，无法进行荟萃分析。与糖皮质激素单药治疗相比，联合使用锌并未改善症状。
考虑到研究数量有限且缺乏充分证据，目前无法就锌对OLP的影响得出明确结论。
