State Key Laboratory of Bioengineering Reactor and School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.
Chem Commun (Camb). 2019 Dec 3;55(97):14657-14660. doi: 10.1039/c9cc07184a.
A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields.
发展了一种光氧化还原/镍双催化的糖苷酸与芳基/杂芳基溴化物的脱羧交叉偶联反应。该反应在可见光照射下顺利进行，具有使用成本效益高且易于处理的催化剂和起始原料的特点，可在中等至较高收率下高度立体选择性地合成各种芳基/杂芳基-C-核苷。
