Saleem Fatima, Sharma Ashish
King Edward Medical University
Yuma Regional Medical Center
Drug or pill-induced esophagitis is esophageal mucosal injury caused by the medications and usually refers to a direct toxic effect on esophageal mucosa by the culprit medication. Common symptoms include retrosternal pain, dysphagia, or odynophagia. It was first reported in 1970 by Pemberton when a patient was found to have esophageal ulcers after taking potassium chloride tablets. Drugs can be damaging to the esophageal wall by having a direct toxic effect on the esophageal mucosa, which produces a caustic effect by creating an acidic or alkaline environment. Drug-induced esophagitis can be self-limiting esophagitis, but if persistent, then it can lead to complications such as severe ulceration, strictures, and rarely even perforation. Gastroesophageal reflux disease can aggravate drug-induced esophagitis. This activity will review Drug-induced esophagitis clinical manifestations, etiology, pathophysiology, diagnosis, and management.
药物或药丸性食管炎是由药物引起的食管黏膜损伤，通常指罪魁祸首药物对食管黏膜的直接毒性作用。常见症状包括胸骨后疼痛、吞咽困难或吞咽痛。1970年彭伯顿首次报告了一名患者在服用氯化钾片后出现食管溃疡的情况。药物可通过对食管黏膜产生直接毒性作用而损害食管壁，通过创造酸性或碱性环境产生腐蚀性作用。药物性食管炎可以是自限性食管炎，但如果持续存在，则可导致严重溃疡、狭窄等并发症，甚至罕见的穿孔。胃食管反流病可加重药物性食管炎。本活动将综述药物性食管炎的临床表现、病因、病理生理学、诊断和管理。
