Akayzin E S, Metelev A S, Akayzina A E
Ivanovo State Medical Academy, 153012, Ivanovo, Russian Federation.
Ivanovo Regional Clinical Hospital, 153040, Ivanovo, Russian Federation.
Klin Lab Diagn. 2019;64(11):644-648. doi: 10.18821/0869-2084-2019-64-11-644-648.
The aim of the study was to assess the information content of volatile fatty acid parameters for the differential diagnosis of infected and sterile pancreatic necrosis. The work is based on the results of examination and treatment of 34 patients with pancreatic necrosis. The analysis of concentrations of volatile fatty acids: acetic, propionic, butyric and isovaleric was carried out on an automated gas chromatograph «Crystallux-4000» with a capillary column «HP-FFAP» and flame ionization detector. The indicators of acetic, propionic, butyric, isovaleric acid and the sum of volatile fatty acids are statistically significantly higher in patients with infected pancreatic necrosis compared with the indicators of volatile fatty acids in patients with sterile pancreatic necrosis. Volatile fatty acid values can be used for the differential diagnosis of infected and sterile pancreatic necrosis.
本研究的目的是评估挥发性脂肪酸参数对感染性和无菌性胰腺坏死鉴别诊断的信息含量。该研究基于对34例胰腺坏死患者的检查和治疗结果。使用配备毛细管柱“HP-FFAP”和火焰离子化检测器的自动气相色谱仪“Crystallux-4000”对挥发性脂肪酸(乙酸、丙酸、丁酸和异戊酸)的浓度进行分析。与无菌性胰腺坏死患者的挥发性脂肪酸指标相比,感染性胰腺坏死患者的乙酸、丙酸、丁酸、异戊酸指标以及挥发性脂肪酸总和在统计学上显著更高。挥发性脂肪酸值可用于感染性和无菌性胰腺坏死的鉴别诊断。