Department of Medicine 1, University of Erlangen-Nürnberg, Kussmaul Campus for Medical Research, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.
Department of Medicine 1, University of Erlangen-Nürnberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
Immunity. 2019 Nov 19;51(5):791-793. doi: 10.1016/j.immuni.2019.10.011.
The cytokine TNF is thought to play a major role in the immunopathogenesis of ulcerative colitis, and anti-TNF antibodies are considered as cornerstones of clinical therapy. Two clinical trials published in The New England Journal of Medicine now challenge this paradigm and suggest new avenues for research.
细胞因子 TNF 被认为在溃疡性结肠炎的免疫发病机制中起主要作用，抗 TNF 抗体被认为是临床治疗的基石。现在，《新英格兰医学杂志》上发表的两项临床试验挑战了这一模式，并为研究开辟了新途径。
