Sun Lulu, Kong Ruixue, Li Hua, Wang Dashan
Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, China.
Research Center, Shandong Medical College, Linyi, Shandong 276000, China.
Gastroenterol Res Pract. 2021 Aug 23;2021:9621738. doi: 10.1155/2021/9621738. eCollection 2021.
T follicular helper (Tfh) cells represent a novel subset of CD4 T cells which can provide critical help for germinal center (GC) formation and antibody production. The Tfh cells are characterized by the expression of CXC chemokine receptor 5 (CXCR5), programmed death 1 (PD-1), inducible costimulatory molecule (ICOS), B cell lymphoma 6 (BCL-6), and the secretion of interleukin-21 (IL-21). Given the important role of Tfh cells in B cell activation and high-affinity antibody production, Tfh cells are involved in the pathogenesis of many human diseases. Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases characterized by symptoms such as diarrhea, abdominal pain, and weight loss. Ulcerative colitis (UC) and Crohn's disease (CD) are the most studied types of IBD. Dysregulated mucosal immune response plays an important role in the pathogenesis of IBD. In recent years, many studies have identified the critical role of Tfh cells and IL-21 in the pathogenic process IBD. In this paper, we will discuss the role of Tfh cells and IL-21 in IBD pathogenesis.
滤泡辅助性T（Tfh）细胞是CD4 T细胞的一个新亚群，可为生发中心（GC）形成和抗体产生提供关键帮助。Tfh细胞的特征在于表达CXC趋化因子受体5（CXCR5）、程序性死亡1（PD-1）、诱导性共刺激分子（ICOS）、B细胞淋巴瘤6（BCL-6），并分泌白细胞介素-21（IL-21）。鉴于Tfh细胞在B细胞活化和高亲和力抗体产生中的重要作用，Tfh细胞参与了许多人类疾病的发病机制。炎症性肠病（IBD）是一组以腹泻、腹痛和体重减轻等症状为特征的慢性炎症性疾病。溃疡性结肠炎（UC）和克罗恩病（CD）是研究最多的IBD类型。黏膜免疫反应失调在IBD的发病机制中起重要作用。近年来，许多研究已经确定了Tfh细胞和IL-21在IBD致病过程中的关键作用。在本文中，我们将讨论Tfh细胞和IL-21在IBD发病机制中的作用。
