Shaikh M B, Edinger H M, Siegel A
Department of Neurosciences, New Jersey Medical School, Newark 07103.
Pharmacol Biochem Behav. 1988 Jun;30(2):409-15. doi: 10.1016/s0091-3057(88)80001-7.
Carbamazepine has been utilized both as an anticonvulsant and as a psychotropic drug for the treatment of complex partial seizures and various mood and other emotional disorders such as the episodic dyscontrol syndrome. In the present study, we sought to identify the role of carbamazepine in the regulation of two forms of aggressive behavior--affective defense and quiet biting attack behavior--elicited by electrical stimulation of the midbrain periaqueductal gray matter of the cat in the absence of convulsive activity. The experimental paradigm involved establishment of stable baseline thresholds for affective defense and quiet biting attack responses. Following establishment of a stable baseline, carbamazepine (2.5, 5, or 10 mg/kg) and propylene glycol (vehicle control) were administered peripherally (IP). The response thresholds were tested 5-30, 30-60, 60-90, 120-150, 1440-1470, and 2160-2190 minutes following drug administration. It was observed that carbamazepine administration at 5 and 10 mg/kg dose levels preferentially suppressed affective defense behavior but had no effect upon quiet biting attack, indicating that the selective effects of carbamazepine upon affective attack are not due to any possible sedative effects upon motor responses. The effects of carbamazepine upon affective defense were dose dependent and of long duration when administered at the highest dose level (10 mg/kg).
卡马西平既被用作抗惊厥药，也被用作精神药物，用于治疗复杂部分性癫痫发作以及各种情绪和其他情感障碍，如发作性失控综合征。在本研究中，我们试图确定卡马西平在调节两种攻击行为——情感防御和安静撕咬攻击行为——中的作用，这两种行为是在猫的中脑导水管周围灰质电刺激下，在无惊厥活动的情况下引发的。实验范式包括建立情感防御和安静撕咬攻击反应的稳定基线阈值。在建立稳定基线后，卡马西平（2.5、5或10毫克/千克）和丙二醇（载体对照）经外周（腹腔注射）给药。在给药后5 - 30、30 - 60、60 - 90、120 - 150、1440 - 1470和2160 - 2190分钟测试反应阈值。观察到以5毫克/千克和10毫克/千克剂量水平给药的卡马西平优先抑制情感防御行为，但对安静撕咬攻击没有影响，这表明卡马西平对情感攻击的选择性作用不是由于对运动反应的任何可能的镇静作用。当以最高剂量水平（10毫克/千克）给药时，卡马西平对情感防御的作用是剂量依赖性的且持续时间长。
