Domer F R, Wessler G, Brown R L, Matthews A
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112.
Pharmacol Biochem Behav. 1988 Jun;30(2):543-5. doi: 10.1016/0091-3057(88)90495-9.
Male cats were anesthetized with pentobarbital. A Foley catheter was placed in the urinary bladder and physiologic saline, under a head of pressure, was allowed to flow at a constant rate through the bladder. Naloxone, 0.2 mg, caused penile erection in 5 of 11 experiments. The onset of action was 0.5 to 4 minutes, and the duration of the erection was 5 to 36 minutes. In two of three experiments a second injection of naloxone caused a second erection. The erection caused by naloxone was not changed by pre- or posttreatment with morphine or by posttreatment with propranolol. It was suggested that the erection could be due either to altered levels of hormones released from the central nervous system or to removal of reflex inhibitory tone in the spinal cord or sacral parasympathetic ganglia.
雄性猫用戊巴比妥麻醉。将一根福勒氏导尿管插入膀胱，并在压力作用下，让生理盐水以恒定速率流经膀胱。在11次实验中的5次实验里，0.2毫克的纳洛酮引发了阴茎勃起。起效时间为0.5至4分钟，勃起持续时间为5至36分钟。在三次实验中的两次实验里，第二次注射纳洛酮引发了第二次勃起。吗啡预处理或后处理，以及普萘洛尔后处理，均未改变纳洛酮引发的勃起。有人提出，勃起可能是由于中枢神经系统释放的激素水平改变，或是由于脊髓或骶副交感神经节反射抑制张力的消除。
