天然化合物的药理学。I. 银杏叶提取物对豚鼠气管的平滑肌舒张活性。

Pharmacology of natural compounds. I. Smooth muscle relaxant activity induced by a Ginkgo biloba L. extract on guinea-pig trachea.

作者信息

Puglisi L, Salvadori S, Gabrielli G, Pasargiklian R

机构信息

Institute of Pharmacological Sciences, University of Milan, Italy.

出版信息

Pharmacol Res Commun. 1988 Jul;20(7):573-89. doi: 10.1016/s0031-6989(88)80084-5.

DOI:10.1016/s0031-6989(88)80084-5

PMID:3174791

Abstract

A standardized Ginkgo biloba L. extract containing flavonol glycosides induces a concentration-dependent relaxation of guinea-pig trachea in vitro and antagonizes in vivo bronchoconstriction induced by various agonists. The action of the extract appears to be mediated partially by an interaction with the eicosanoid system particularly through specific stimulation of the PGE2 biosynthesis and partially by beta-adrenoceptor activation. The relaxation of guinea-pig trachea induced by the extract is in fact antagonized by indomethacin (2 x 10(-8)M), ETYA (3.4 x 10(-8)M) and sotalol (4 x 10(-6)M). The concentration-response curves obtained with tracheal preparation from reserpinized guinea-pig and those performed in the presence of a glutathione depletor (CDNB 1 x 10(-5)M) are modified in a similar manner confirming that the extract can act on both the systems: adrenergic as well as prostaglandinergic.

摘要

一种含有黄酮醇苷的标准化银杏提取物在体外可诱导豚鼠气管浓度依赖性舒张，并在体内拮抗由各种激动剂引起的支气管收缩。该提取物的作用似乎部分通过与类花生酸系统相互作用介导，特别是通过特异性刺激PGE2生物合成，部分通过β-肾上腺素能受体激活介导。事实上，吲哚美辛（2×10⁻⁸M）、ETYA（3.4×10⁻⁸M）和索他洛尔（4×10⁻⁶M）可拮抗该提取物诱导的豚鼠气管舒张。用利血平化豚鼠的气管制备物获得的浓度-反应曲线以及在谷胱甘肽耗竭剂（CDNB 1×10⁻⁵M）存在下进行的曲线以类似方式改变，证实该提取物可作用于肾上腺素能和前列腺素能这两个系统。