银杏叶提取物对豚鼠离体回肠的作用。

Effect of an extract of Ginkgo biloba on the isolated ileum of the guinea-pig.

Vilain B, DeFeudis F V, Clostre F

Gen Pharmacol. 1982;13(5):401-5. doi: 10.1016/0306-3623(82)90105-7.

Abstract

The effects of an extract of Ginkgo biloba (Gb) were studied using the guinea-pig isolated ileum. 2. Using isometric recording, the dose-response relation for the action of Gb was complex, and at 400 micrograms/ml was reproducibly biphasic--a relaxation followed by a contraction. 3. Droperidol (3 X 10(-7) M - 10(-6) M), cyproheptadine (10(-7) M), and diphenhydramine (10(-7) M) prolonged the relaxation and usually decreased the amplitude of the contraction produced by Gb (400 micrograms/ml), whereas phentolamine, hexamethonium, methysergide, or cimetidine (10(-7) or 10(-6) M) did not affect the response to Gb. 4. The action of Gb on the guinea-pig ileum might involve mechanisms associated with dopamine and/or histamine.

摘要

使用豚鼠离体回肠研究了银杏叶提取物（Gb）的作用。2. 通过等长记录法，Gb作用的剂量反应关系较为复杂，在400微克/毫升时可重复性地呈现双相作用——先是松弛，随后是收缩。3. 氟哌利多（3×10⁻⁷M - 10⁻⁶M）、赛庚啶（10⁻⁷M）和苯海拉明（10⁻⁷M）延长了松弛时间，且通常降低了Gb（400微克/毫升）产生的收缩幅度，而酚妥拉明、六甲铵、麦角新碱或西咪替丁（10⁻⁷或10⁻⁶M）不影响对Gb的反应。4. Gb对豚鼠回肠的作用可能涉及与多巴胺和/或组胺相关的机制。