Fisher J, Yang W Y
Meharry Medical College, HCA Center for Research and Education, Nashville, Tenn. 37203.
Plast Reconstr Surg. 1988 Nov;82(5):857-64. doi: 10.1097/00006534-198811000-00021.
Molding of pig omentum to create external structures, such as the ear or penis, was performed using silicone rubber molds. The omentum was mobilized on its gastroepiploic pedicle and brought out through a fascial defect. The molds containing the omentum were placed beneath the skin and panniculus carnosus for 4 weeks. Split-thickness skin grafts were placed on both surfaces of the mold, and a series of synthetic materials was placed within the omentum to provide structural support. When an appropriate amount of tissue had been placed within the device, omentum took on the contour of the mold. Excessive pressure associated with swelling resulted in necrosis, while an inadequate amount of tissue gave poor contour. Omentum molded without any support material rapidly lost its contour once removed from the mold. Omentum molded in combination with a synthetic material maintained its shape up to 1 month after mold removal in a limited number of animals. This model was designed to create structures with the fine detail of a prosthesis using autologous tissue. This "prosthesis" made from living tissue could then be transferred secondarily to its recipient area by microvascular technique.
使用硅胶橡胶模具对猪网膜进行塑形以制造外部结构，如耳朵或阴茎。网膜在其胃网膜蒂上被游离，并通过筋膜缺损引出。装有网膜的模具置于皮肤和深筋膜下4周。在模具的两个表面放置断层皮片，并在网膜内放置一系列合成材料以提供结构支撑。当装置内放置了适量的组织时，网膜呈现出模具的轮廓。与肿胀相关的过大压力导致坏死，而组织量不足则轮廓不佳。没有任何支撑材料塑形的网膜一旦从模具中取出，很快就会失去其轮廓。在少数动物中，与合成材料结合塑形的网膜在模具移除后长达1个月仍能保持其形状。该模型旨在使用自体组织制造具有假体精细细节的结构。然后，这种由活组织制成的“假体”可通过微血管技术二次转移到其接受区域。
