Radiation Oncology Department, Hospital Clínic, Barcelona, Spain.
Departament de Ciències Clíniques, Radiation Oncology Department, Institut Català d'Oncologia, IDIBELL, Universitat de Barcelona, Barcelona, Spain.
Clin Transl Oncol. 2020 Jul;22(7):1187-1192. doi: 10.1007/s12094-019-02246-0. Epub 2019 Nov 20.
Comorbidity assessment is essential in the triage of care for men with prostate cancer (PC). The aim of this study was to validate the Spanish version of the revised Charlson index (RCI) in PC.
731 PC patients diagnosed from 1993 to 2008 were referred to our Radiation Oncology Department. The RCI classified patients into four categories RCI 0, RCI 1-2, RCI 3-4, and RCI 5 and higher. The Kaplan-Meier method and Cox proportional hazards modeling were used. We also analyzed the median age of patients who remained alive at the last control and those who died due to non-prostate cancer comorbidities.
636 patients were included median age: 70 years (44-85). The mean follow-up was 153.62 months, (6-288 months). Distribution of the D'Amico risk classification was 21%, 38.2%, and 40.8% for low, intermediate, and high risk, respectively. The RCI distribution categories were: 303 (46.7%) RCI 0, 102 (16%) RCI 1-2, 131 (20.6%) RCI 3-4, and 100 (15.7%) RCI 5 and higher. The probability of non-cause-specific mortality at 5 and 10 years was 2. 4% and 11.25% RCI 0, 3 and 14.1% RCI 1-2, 5.7% and 22.1% RCI 3-4, and 47% and 92% (RCI 5 and higher). The median age in the last control in patients alive or who had died by non-PC causes was 82.81 years (55.27-102).
The RCI may be used to aid medical decision making in older Spanish men with PC, especially in those with a high RCI 5 and higher.
合并症评估对于前列腺癌 (PC) 患者的护理分诊至关重要。本研究旨在验证修订版 Charlson 指数 (RCI) 的西班牙语版本在 PC 中的适用性。
1993 年至 2008 年间，我们放射肿瘤科共收治了 731 例 PC 患者。RCI 将患者分为 4 个类别：RCI 0、RCI 1-2、RCI 3-4 和 RCI 5 及更高。采用 Kaplan-Meier 方法和 Cox 比例风险模型进行分析。我们还分析了最后一次随访时仍存活的患者和因非前列腺癌合并症而死亡的患者的中位年龄。
共纳入 636 例患者，中位年龄为 70 岁（44-85 岁）。平均随访时间为 153.62 个月（6-288 个月）。D'Amico 风险分类的分布分别为低危 21%、中危 38.2%和高危 40.8%。RCI 分布类别为：303 例（46.7%）RCI 0、102 例（16%）RCI 1-2、131 例（20.6%）RCI 3-4 和 100 例（15.7%）RCI 5 及更高。RCI 0、RCI 1-2、RCI 3-4 和 RCI 5 及更高的 5 年和 10 年非病因特异性死亡率分别为 2.4%和 11.25%、3%和 14.1%、5.7%和 22.1%以及 47%和 92%。存活患者和因非 PC 原因死亡患者的最后一次随访时的中位年龄为 82.81 岁（55.27-102 岁）。
RCI 可用于辅助西班牙老年 PC 患者的医疗决策，尤其是那些 RCI 5 及更高的患者。
