Nazemiyeh Masoud, Nouri-Vaskeh Masoud, Somi Mohammad Hossein, Saeedi Ehsan, Sharifi Akbar
Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Gastroenterol Hepatol Bed Bench. 2019 Fall;12(4):287-291.
This research aimed to evaluate the effect of gastroesophageal reflux disease (GERD) on pulmonary volumes, airflows, and airway resistance in the patients without respiratory symptoms and compare them with the healthy subjects.
GERD is the return of gastric content into the esophagus and beyond. GERD may play an essential role in the extraesophageal diseases, including chest pain, asthma, laryngitis, chronic cough, and sinusitis. The relation between GERD and airway involvement in asthma and also bronchoconstrictor effects of GERD are well recognized, but its impact on lung parameters in the patients with GERD without respiratory symptoms is unclear.
In a case-control study, 78 GERD patients without pulmonary symptoms and 93 healthy subjects as control group were enrolled. The impulse oscillometry examined airway resistance. The body plethysmograph measured the pulmonary volumes and airflows.
The mean age of GERD patients and the healthy subjects were 37.30±9.76 and 34.74±11.10, respectively. A total of 53.8% of patients and 67.7% of healthy subjects were male. The lung volumes measured by the body plethysmography were normal in both patients and healthy subjects. However, there was a significant difference between the groups in forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) (P=0.01) and maximal mid expiratory flow (MMEF) (P=0.008). Airway resistance at R5Hz was significantly higher in the case group than the control group (P=0.001).
The results of the current study demonstrated that GERD patients have small airway disease even in the absence of respiratory symptoms.
本研究旨在评估胃食管反流病（GERD）对无呼吸道症状患者的肺容积、气流和气道阻力的影响，并将其与健康受试者进行比较。
GERD是胃内容物反流至食管及食管以外部位。GERD可能在食管外疾病中起重要作用，包括胸痛、哮喘、喉炎、慢性咳嗽和鼻窦炎。GERD与哮喘气道受累之间的关系以及GERD的支气管收缩作用已得到充分认识，但其对无呼吸道症状的GERD患者肺参数的影响尚不清楚。
在一项病例对照研究中，纳入78例无肺部症状的GERD患者和93例健康受试者作为对照组。采用脉冲振荡法检测气道阻力。用体容积描记仪测量肺容积和气流。
GERD患者和健康受试者的平均年龄分别为37.30±9.76岁和34.74±11.10岁。患者组和健康受试者组分别有53.8%和67.7%为男性。两组患者通过体容积描记法测量的肺容积均正常。然而，两组在1秒用力呼气容积（FEV1）/用力肺活量（FVC）（P=0.01）和最大呼气中期流速（MMEF）（P=0.008）方面存在显著差异。病例组R5Hz时的气道阻力显著高于对照组（P=0.001）。
本研究结果表明，即使在无呼吸道症状的情况下，GERD患者也存在小气道疾病。
