Krill Timothy, Baliss Michelle, Zaibaq Jenine, Abdulla Hamza M, Parupudi Sreeram
Department of Gastroenterology and Hepatology, The University of Texas Medical Branch, Texas, USA.
Department of Internal Medicine, The University of Texas Medical Branch, Texas, USA.
Gastroenterol Hepatol Bed Bench. 2019 Fall;12(4):370-373.
Malignancy can induce a hypercoagulable state and lead to an increased risk of thromboembolic events. The pathogenesis of the prothrombotic state in cancer is complicated but is thought to involve several mechanisms. Thrombosis predominantly affects the venous circulation and infrequently the arteries. Arterial occlusion as an initial manifestation of acute leukemia is unusual. This is a case of a 44-year-old male admitted with complete thrombotic occlusion of the superior mesenteric artery and treated with emergent thrombectomy. Hematologic work-up was consistent with a diagnosis of T-cell acute lymphoblastic leukemia. To our knowledge, this is the first case of complete occlusion of the superior mesenteric artery presenting as the initial manifestation of T-cell acute lymphoblastic leukemia.
恶性肿瘤可引发高凝状态并导致血栓栓塞事件风险增加。癌症患者血栓前状态的发病机制复杂，但被认为涉及多种机制。血栓形成主要影响静脉循环，很少影响动脉。急性白血病以动脉闭塞为首发表现并不常见。本文报告一例44岁男性患者，因肠系膜上动脉完全血栓闭塞入院，接受了急诊血栓切除术。血液学检查结果符合T细胞急性淋巴细胞白血病的诊断。据我们所知，这是首例以肠系膜上动脉完全闭塞为T细胞急性淋巴细胞白血病首发表现的病例。
