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慢性化脓性中耳炎的细菌学特征及抗菌药物敏感性模式:一项为期1年的横断面研究

Bacteriological Profile and Antimicrobial Susceptibility Pattern in Chronic Suppurative Otitis Media: A 1-Year Cross-Sectional Study.

作者信息

Hiremath Basavaraj, Mudhol R S, Vagrali Manjula A

机构信息

Department of Otorhinolaryngology and Head and Neck Surgery, K.L.E. University's Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka 590003 India.

Department of Microbiology, K.L.E. University's Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka 590003 India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 2):1221-1226. doi: 10.1007/s12070-018-1279-6. Epub 2018 Feb 21.

Abstract

Inadequate antibiotic treatment, misuse/improper choice of antibiotic and poor compliance of patients have resulted in changes in susceptibility to antibiotics of the causative organisms and also development of resistance to commonly used antibiotics. Thus, this study aimed to identify the bacteriological profile and determine antibiotic susceptibility pattern in CSOM patients. This 1-year cross-sectional study was conducted on 120 clinically diagnosed cases of CSOM attending ear, nose, and throat outpatient department. Ear discharges obtained were processed for bacterial culture (aerobic and anaerobic). Antimicrobial susceptibility testing was done by Kirby-Bauer disc diffusion method. Demographic and clinical characteristics of the patients were recorded. Of total 120 cases, pathogens were isolated from 116 cases. The commonest aerobic organism isolated was (38.79%) followed by (32.75%). showed maximum sensitivity to erythromycin (71.05%), followed by cotrimoxazole (63.15%) and ampicillin (55.26%). Maximum resistance was observed for ciprofloxacin (78.9%), followed by amoxiclave (55.26%). showed maximum sensitivity to piperacillin (91.11%) followed by gentamicin (71.11%), amikacin (71.11%), moderate sensitivity to ceftazidime (51.11%); however resistance to carbpenicillin (60%). Ciprofloxacin was the most prescribed topical agent showing an increase in resistance to common organisms of CSOM. Hence, it is mandatory to study each case of CSOM bacteriologically to formulate local antibiotic policy for appropriate use of antibiotics. This will certainly help in achieving a safe ear and to control the organisms developing resistance to prevalent antibiotics.

摘要

抗生素治疗不足、抗生素的误用/选择不当以及患者依从性差,已导致致病微生物对抗生素的敏感性发生变化,同时也产生了对常用抗生素的耐药性。因此,本研究旨在确定慢性化脓性中耳炎(CSOM)患者的细菌学特征并确定抗生素敏感性模式。这项为期1年的横断面研究针对120例临床诊断为CSOM的患者,这些患者在耳鼻喉科门诊就诊。获取的耳部分泌物进行细菌培养(需氧和厌氧)。采用 Kirby-Bauer 纸片扩散法进行药敏试验。记录患者的人口统计学和临床特征。在总共120例病例中,从116例中分离出病原体。分离出的最常见需氧菌是[具体细菌名称1](38.79%),其次是[具体细菌名称2](32.75%)。[具体细菌名称1]对红霉素的敏感性最高(71.05%),其次是复方新诺明(63.15%)和氨苄西林(55.26%)。对环丙沙星的耐药性最高(78.9%),其次是阿莫西林克拉维酸(55.26%)。[具体细菌名称2]对哌拉西林的敏感性最高(91.11%),其次是庆大霉素(71.11%)、阿米卡星(71.11%),对头孢他啶的敏感性中等(51.11%);然而对羧苄青霉素耐药(60%)。环丙沙星是最常开具的局部用药,对CSOM常见病原体的耐药性呈上升趋势。因此,必须对每例CSOM病例进行细菌学研究,以制定局部抗生素政策,合理使用抗生素。这肯定有助于实现耳部健康并控制对常用抗生素产生耐药性的微生物。

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