College of Food Science, Southwest University, No. 2 Tian Shengqiao, Beibei, Chongqing, P. R. China.
Food Funct. 2019 Dec 11;10(12):7967-7972. doi: 10.1039/c9fo02127b.
Efficient treatment of hypertension is vital. The inhibition of angiotensin-converting enzyme activity has been one of the major strategies for treating hypertension. The ethanol extract of stevia leaves, steviol glycosides (with 95% purity; natural sweeteners widely used in the food industry) isolated from the ethanol extract and stevia leaf protein hydrolysates inhibited 26.60%, 59.56% and 74.38% of angiotensin-converting enzyme activities, respectively. Their effect was dose-dependent, which can be beneficial for avoiding hypertension or hypotension just by the proper control of the amount of their intake, and it was found to be superior to that of pharmaceutical drugs. A sensory test indicated that the application of the mixtures of steviol glycosides and stevia protein hydrolysates to decaffeinated coffee or tea as well as a formulated peanut protein drink was found to be well accepted, and an animal test showed that they had a significantly antihypertensive effect in spontaneously hypertensive rats. Steviol glycosides and stevia leaf protein hydrolysates can be good ingredients for making functional or healthy food products or beverages targeted for the prevention or treatment of hypertension.
有效治疗高血压至关重要。抑制血管紧张素转化酶活性一直是治疗高血压的主要策略之一。从甜叶菊叶乙醇提取物中分离出的甜菊醇糖苷（纯度为 95%，是食品工业中广泛使用的天然甜味剂）和甜菊叶蛋白水解物分别抑制了 26.60%、59.56%和 74.38%的血管紧张素转化酶活性。其效果呈剂量依赖性，通过适当控制摄入量，可以避免高血压或低血压，这比药物更有优势。感官测试表明，将甜菊醇糖苷和甜菊叶蛋白水解物混合物应用于脱咖啡因咖啡或茶以及配制的花生蛋白饮料中，结果被广泛接受，动物试验表明，它们对自发性高血压大鼠具有显著的降压作用。甜菊醇糖苷和甜菊叶蛋白水解物可以成为功能性或健康食品或饮料的良好成分，这些产品或饮料针对高血压的预防或治疗。
