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病原体下一代测序时代的精准医学和精准公共卫生。

Precision Medicine and Precision Public Health in the Era of Pathogen Next-Generation Sequencing.

机构信息

Laboratorio de Genómica, Pontificia Universidad Católica del Perú, Lima.

Departamento de Bioloxía Celular e Molecular, Facultade de Ciencias, Universidade de A Coruña, Spain.

出版信息

J Infect Dis. 2020 Mar 28;221(Suppl 3):S289-S291. doi: 10.1093/infdis/jiz424.

Abstract

This brief report serves as an introduction to a supplement of the Journal of Infectious Diseases entitled "Next-Generation Sequencing (NGS) Technologies to Advance Global Infectious Disease Research." We briefly discuss the history of NGS technologies and describe how the techniques developed during the past 40 years have impacted our understanding of infectious diseases. Our focus is on the application of NGS in the context of pathogen genomics. Beyond obvious clinical and public health applications, we also discuss the challenges that still remain within this rapidly evolving field.

摘要

本简要报告作为《传染病杂志》增刊的引言,该增刊题为“推进全球传染病研究的下一代测序(NGS)技术”。我们简要讨论了 NGS 技术的历史,并描述了过去 40 年来开发的技术如何影响我们对传染病的理解。我们的重点是 NGS 在病原体基因组学方面的应用。除了明显的临床和公共卫生应用外,我们还讨论了这个快速发展领域中仍然存在的挑战。

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