CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus Universitário da Penteada, 9020-105 Funchal, Portugal.
CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus Universitário da Penteada, 9020-105 Funchal, Portugal; Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, rue des Saints Peres, 75006 Paris, France.
J Control Release. 2020 Jan 10;317:347-374. doi: 10.1016/j.jconrel.2019.11.016. Epub 2019 Nov 18.
Cancer is one of the leading causes of death worldwide and, as such, efforts are being done to find new chemotherapeutic drugs or, alternatively, novel approaches for the delivery of old ones. In this scope, when used as vehicles for drugs, nanomaterials may potentially maximize the efficacy of the treatment and reduce its side effects, for example by a change in drug's pharmacokinetics, cell targeting and/or specific stimuli-responsiveness. This is the case of doxorubicin (DOX) that presents a broad spectrum of activity and is one of the most widely used chemotherapeutic drugs as first-line treatment. Indeed, DOX is a very interesting example of a drug for which several nanosized delivery systems have been developed over the years. While it is true that some of these systems are already in the market, it is also true that research on this subject remains very active and that there is a continuing search for new solutions. In this sense, this review takes the example of doxorubicin, not so much with the focus on the drug itself, but rather as a case study around which very diverse and imaginative nanotechnology approaches have emerged.
癌症是全球主要死因之一，因此，人们正在努力寻找新的化疗药物，或者寻找新的方法来输送旧的化疗药物。在这方面，纳米材料可用作药物载体，有可能最大限度地提高治疗效果，并减少其副作用，例如通过改变药物的药代动力学、细胞靶向和/或特定的刺激响应性。阿霉素（DOX）就是一个很好的例子，它具有广泛的活性，是最广泛使用的一线化疗药物之一。事实上，DOX 是一个非常有趣的药物范例，多年来已经开发出了多种纳米给药系统。虽然其中一些系统已经在市场上，但研究仍然非常活跃，并且一直在寻找新的解决方案。从这个意义上说，本综述以阿霉素为例，重点不是放在药物本身，而是将其作为一个案例研究，围绕它出现了非常多样化和富有想象力的纳米技术方法。
