Division of Gastrointestinal and Liver Diseases, Keck School of Medicine of University of Southern California, Los Angeles, California.
Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California.
Clin Gastroenterol Hepatol. 2021 Feb;19(2):397-399. doi: 10.1016/j.cgh.2019.11.024. Epub 2019 Nov 18.
Within the spectrum of autoimmune liver diseases, there are patients who manifest features of more than one disease, which was previously identified as having overlap syndrome and is now referred to as variant syndromes. The most common variant syndrome is between primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). Typically, AIH presents with elevated serum immunoglobulin (Ig) G, whereas PBC is associated with elevated serum IgM. Previous studies have suggested that plasma cells in liver biopsies of AIH patients are predominantly IgG+, whereas in PBC, there is an abundance of IgM+ cells. We wanted to determine the immunostaining pattern for IgG and IgM of liver plasma cells among Hispanic patients in Los Angeles with features of both PBC-AIH compared with those with PBC or AIH alone.
在自身免疫性肝病谱中，有些患者表现出一种以上疾病的特征，以前被确定为重叠综合征，现在称为变异综合征。最常见的变异综合征是原发性胆汁性胆管炎（PBC）和自身免疫性肝炎（AIH）之间。通常，AIH 表现为血清免疫球蛋白（Ig）G 升高，而 PBC 与血清 IgM 升高有关。以前的研究表明，AIH 患者肝活检中的浆细胞主要为 IgG+，而在 PBC 中，则存在大量 IgM+细胞。我们想确定洛杉矶具有 PBC-AIH 特征的西班牙裔患者与单纯 PBC 或 AIH 患者的肝浆细胞 IgG 和 IgM 的免疫染色模式。
