Faculty of Medicine, Institute of Health and Society, Department of Nursing Science, University of Oslo, Oslo, Norway; Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.
Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Colorectal Cancer Research Centre, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.
Eur J Oncol Nurs. 2020 Feb;44:101679. doi: 10.1016/j.ejon.2019.101679. Epub 2019 Nov 18.
Multiple symptoms can have a negative impact on quality of life (QoL), but there is little information about the impact of multiple symptoms on QoL of patients with colorectal cancer (CRC) during outpatient chemotherapy. Therefore, the purpose was to assess the physical and mental QoL in CRC patients over six months of chemotherapy, to evaluate the association of QoL with the presence of multiple symptoms, and to determine which demographic and clinical characteristics are associated with physical and mental QoL scores.
Outpatients with CRC (N = 120) completed the Medical Outcomes Study Short Form (SF-12) and Memorial Symptom Assessment Scale (MSAS) at eight time points during six months of chemotherapy. Linear mixed models for repeated measures were used to analyse QoL over time; and its association with demographic and clinical characteristics; and with the presence of multiple symptoms (e.g., 'numbness/tingling' and 'problems with sexual interest').
The CRC patients had worse physical and mental QoL scores than the general population at all time points. Impaired physical QoL was significantly associated with psychological symptom burden (p < 0.001) and numbness/tingling (p < 0.027). Impaired mental QoL was associated with physical symptom burden (p < 0.001), with being female (p < 0.009), younger age (p < 0.024), and having problems with sexual interest (p < 0.009).
Impaired QoL was associated with symptoms in CRC outpatients. This information about the symptoms and characteristics associated with worse QoL during chemotherapy may help clinicians identify and inform at-risk patients.
多种症状会对生活质量（QoL）产生负面影响，但关于结直肠癌（CRC）患者在门诊化疗期间多种症状对 QoL 的影响的信息较少。因此，本研究的目的是评估 CRC 患者在化疗 6 个月期间的身心 QoL，评估 QoL 与多种症状的相关性，并确定哪些人口统计学和临床特征与身心 QoL 评分相关。
120 例 CRC 门诊患者在化疗的 6 个月期间的 8 个时间点完成了医疗结局研究简表（SF-12）和纪念症状评估量表（MSAS）。采用重复测量线性混合模型分析 QoL 随时间的变化；及其与人口统计学和临床特征的相关性；以及与多种症状（如“麻木/刺痛”和“性兴趣问题”）的存在的相关性。
CRC 患者在所有时间点的身心 QoL 评分均低于一般人群。身体 QoL 受损与心理症状负担显著相关（p<0.001）和麻木/刺痛（p<0.027）。心理 QoL 受损与身体症状负担相关（p<0.001），与女性（p<0.009）、年龄较小（p<0.024）和存在性兴趣问题（p<0.009）有关。
身心 QoL 受损与 CRC 门诊患者的症状有关。这些关于在化疗期间与较差 QoL 相关的症状和特征的信息可能有助于临床医生识别和告知高危患者。
