Department of Pediatrics, National Jewish Health, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, USA.
Sleep Med. 2020 Jan;65:134-141. doi: 10.1016/j.sleep.2019.07.014. Epub 2019 Jul 23.
Insufficient sleep is associated with a number of negative health outcomes; as most adolescents obtain <7 h of sleep per night, it is important to understand how sleep impacts asthma among adolescents.
To examine the impact of sleep opportunity on asthma in adolescents.
In this study, 54 adolescents with asthma (12-17 years, 69% female, 65% Caucasian) participated in a randomized, cross-over sleep manipulation trial, including a sleep stabilization week, five nights of a "Short" sleep opportunity (time in bed: 6.5 h/night), and five nights of a "Long" sleep opportunity (time in bed: 9.5 h/night). Wake times were consistent across all three study weeks. Primary outcomes were lung function (daily peak expiratory flow rate, weekly spirometry) and functional asthma outcomes (daily asthma symptoms, Asthma Control Questionnaire, PROMIS Asthma Impact Scale). Markers of inflammation were also explored.
Compared to the Long sleep week, during the Short sleep week, morning FEV1 was lower (p = 0.006), while asthma symptoms and albuterol use was higher (p < 0.05), and asthma showed a trend towards greater negative impact on daily life (p = 0.07). No differences were found for weekly measures of lung function or inflammation.
An insufficient sleep opportunity negatively impacts objective and subjective daily symptoms of asthma in adolescents, as well as health related quality of life. As most adolescents are significantly sleep deprived, it is important to target sleep health in the treatment of asthma.
睡眠不足与许多负面健康后果有关；由于大多数青少年每晚的睡眠时间都不足 7 小时，因此了解睡眠如何影响青少年的哮喘非常重要。
研究睡眠机会对青少年哮喘的影响。
在这项研究中，54 名患有哮喘的青少年（12-17 岁，69%为女性，65%为白种人）参加了一项随机、交叉睡眠干预试验，包括睡眠稳定周、五个晚上的“短”睡眠机会（卧床时间：每晚 6.5 小时）和五个晚上的“长”睡眠机会（卧床时间：每晚 9.5 小时）。所有三个研究周的醒来时间都是一致的。主要结局指标是肺功能（每日呼气峰值流速、每周肺活量测定）和功能性哮喘结局（每日哮喘症状、哮喘控制问卷、PROMIS 哮喘影响量表）。还探讨了炎症标志物。
与长睡眠周相比，在短睡眠周期间，早晨 FEV1 较低（p=0.006），而哮喘症状和沙丁胺醇使用较高（p<0.05），哮喘对日常生活的负面影响也更大（p=0.07）。每周的肺功能或炎症测量没有差异。
睡眠机会不足会对青少年的哮喘客观和主观日常症状以及健康相关生活质量产生负面影响。由于大多数青少年都严重睡眠不足，因此在治疗哮喘时，重视睡眠健康非常重要。
