Li Jingyang, Qian Xiaoqian, Ding Guodong, Zhang Yongjun
Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
Renal Division, Department of Internal Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
BMC Public Health. 2024 Dec 18;24(1):3530. doi: 10.1186/s12889-024-21024-4.
Sleep's impact on the human immune system and inflammatory responses makes it a potential risk factor for lung function impairment. However, the relationship between sleep duration and lung function impairment in middle-aged and young adults has been rarely investigated.
A total of 9,284 aged 20-64 years were categorized into four groups according to sleep duration (≤ 6 h, 7 h, 8 h, and ≥ 9 h), with 7 h as the reference, by using the U.S. NHANES data, 2007-2012. Forced expiratory volume in the 1 s (FEV), forced vital capacity (FVC), FEV to FVC (FEV/FVC) ratio, peak expiratory flow (PEF), and forced expiratory flow at 25-75% (FEF) were measured by spirometry. Restrictive impairment was defined as baseline FVC < 80% predicted and obstructive impairment as FEV/FVC < 0.70. Generalized linear regression and logistic regression were performed to estimate the associations between sleep duration and lung function.
Compared with 7 h of sleep duration, shorter and longer sleep duration were associated with decreases in FEV (≤ 6 h: β=-0.010, 95% CI=-0.014 to -0.006; 8 h: β=-0.005, 95% CI=-0.009 to -0.001), FVC (≤ 6 h: β=-0.018, 95% CI=-0.014 to -0.007; 8 h: β=-0.005, 95% CI=-0.009 to -0.002), and PEF (≤ 6 h: β=-0.006, 95% CI=-0.010 to -0.002; 8 h: β=-0.007, 95% CI=-0.011 to -0.002; ≥ 9 h: β=-0.012, 95% CI=-0.020 to -0.004). Similarly, shorter (≤ 6 h: OR = 1.346, 95% CI = 1.065 to 1.700) and longer (≥ 9 h: OR = 1.827, 95% CI = 1.236 to 2.700) sleep duration were associated with increased risks of restrictive impairment. Moreover, the aforementioned associations were more pronounced among male participants.
Compared with 7 h of sleep duration, shorter and longer sleep duration were associated with impaired lung function among adults aged 20-64 years, and these associations were stronger among males.
睡眠对人体免疫系统和炎症反应的影响使其成为肺功能损害的潜在危险因素。然而，中青年人群的睡眠时间与肺功能损害之间的关系鲜有研究。
利用2007 - 2012年美国国家健康与营养检查调查（NHANES）数据，将9284名年龄在20 - 64岁的研究对象按睡眠时间（≤6小时、7小时、8小时和≥9小时）分为四组，以7小时为参照组。通过肺活量测定法测量第1秒用力呼气容积（FEV）、用力肺活量（FVC）、FEV与FVC的比值（FEV/FVC）、呼气峰值流速（PEF）以及25% - 75%用力呼气流量（FEF）。限制性损害定义为基线FVC低于预测值的80%，阻塞性损害定义为FEV/FVC低于0.70。采用广义线性回归和逻辑回归来评估睡眠时间与肺功能之间的关联。
与睡眠时间为7小时相比，较短和较长睡眠时间均与FEV降低相关（≤6小时：β = -0.010，95%置信区间 = -0.014至 -0.006；8小时：β = -0.005，95%置信区间 = -0.009至 -0.001），FVC降低相关（≤6小时：β = -0.018，95%置信区间 = -0.014至 -0.007；8小时：β = -0.005，95%置信区间 = -0.009至 -0.002），以及PEF降低相关（≤6小时：β = -0.006，95%置信区间 = -0.010至 -0.002；8小时：β = -0.007，95%置信区间 = -0.011至 -0.002；≥9小时：β = -0.012，95%置信区间 = -0.020至 -0.004）。同样，较短（≤6小时：比值比[OR] = 1.346，95%置信区间 = 1.065至1.700）和较长（≥9小时：OR = 1.827，95%置信区间 = 1.236至2.700）睡眠时间与限制性损害风险增加相关。此外，上述关联在男性参与者中更为明显。
与睡眠时间为7小时相比，20 - 64岁成年人中较短和较长睡眠时间均与肺功能受损相关，且这些关联在男性中更强。
