Melbourne School of Psychological Science, The University of Melbourne, Melbourne, VIC, Australia.
School of Psychology, Deakin University, Burwood, VIC, Australia.
Aust N Z J Psychiatry. 2020 Mar;54(3):225-231. doi: 10.1177/0004867419888575. Epub 2019 Nov 22.
In the quest for new treatment options for depression, attention is being paid to the potential role of psychedelic drugs. Psilocybin is of particular interest given its mechanism of action, its benefits in early trials and its relatively low side effects burden. This viewpoint outlines a number of key issues that remain to be elucidated about its potential use in the clinical environment, including clarification of the profile of people most likely to benefit and those who might experience adverse effects, longer-term outcomes and the role of psychotherapeutic input alongside the drug itself. There are also opportunities to understand better, the neurobiology underpinning its effects.
在寻找抑郁症新治疗方案的过程中，人们开始关注致幻药物的潜在作用。鉴于其作用机制、早期试验中的获益以及相对较低的副作用负担，裸盖菇素尤其受到关注。本观点概述了其在临床环境中应用的一些尚未阐明的关键问题，包括明确最有可能获益和可能出现不良反应的人群，长期结果以及心理治疗与药物本身的作用。此外，还有机会更好地了解其作用的神经生物学基础。
