Sánchez-Criado J E, Rothchild I
Departamento de Fisiología, Facultad de Medicina, Universidad de Córdoba, Spain.
Rev Esp Fisiol. 1988 Mar;44(1):99-103.
In 4-day estrous cyclic rats the neutralization of postovulatory biological activity of LH (by means of a single 0.5 ml sc injection of an anti-LH serum) (LHAS) at any time between 12.00 h on estrus and 12.00 h on metestrus prolongs the estrous cycle corpus luteum (CL) progesterone secretion for almost 24 hours. Injection of LHAS later on during the estrous cycle has no effect on CL progesterone secretion. It is concluded that postovulatory LH secreted up to time of CL maximum capacity to produce progesterone (metestrus afternoon) accelerates the intrinsic luteolytic mechanism, and that once the intrinsic luteolytic process has been switched on (shortly after noon of metestrus), it will lead to the CL functional demise regardless of the luteolytic action of LH.
在4天发情周期的大鼠中，在发情期12:00至间情期12:00之间的任何时间，通过单次皮下注射0.5 ml抗促黄体生成素血清（LHAS）中和促黄体生成素（LH）的排卵后生物活性，可使发情周期黄体（CL）孕酮分泌延长近24小时。在发情周期后期注射LHAS对CL孕酮分泌没有影响。得出的结论是，在CL产生孕酮的最大能力时间（间情期下午）之前分泌的排卵后LH会加速内在的黄体溶解机制，并且一旦内在的黄体溶解过程开启（间情期中午过后不久），无论LH的黄体溶解作用如何，都会导致CL功能衰退。
