隐匿性乳腺癌的治疗：基于国家癌症数据库的倾向评分分析。
Treatment for occult breast cancer: A propensity score analysis of the National Cancer Database.
机构信息
University of California, Department of General Surgery, San Diego, United States.
University of California, Department of General Surgery, San Diego, United States.
出版信息
Am J Surg. 2020 Jul;220(1):153-160. doi: 10.1016/j.amjsurg.2019.11.023. Epub 2019 Nov 11.
Abstract
BACKGROUND
Controversy exists regarding optimal treatment of occult breast cancer (OBC). Treatment options include mastectomy alone (MAST), radiation alone (XRT), or mastectomy with radiation (MXRT).
METHODS
We queried the National Cancer Database from 2004 to 2014 for patients with OBC who underwent MAST, XRT, or MXRT. We utilized propensity score matching to perform three head-to-head comparisons. Kaplan-Meier analysis was performed to compare overall survival (OS).
RESULTS
A total of 190 patients received XRT, 237 received MAST, and 244 received MXRT. In the MXRT vs. XRT comparison, 5-year OS was 78.2% and 82.8%, respectively. In the MXRT vs. MAST comparison, 5-year OS was 81.5% and 86.7%, respectively. In the MAST vs. XRT comparison, 5-year OS was 83.2% and 82.5%, respectively. There was no difference in OS for all paired comparisons.
CONCLUSIONS
There were no OS differences in patients undergoing MAST, XRT, or MXRT, suggesting that breast conservation can be considered in patients with OBC.
摘要
背景
隐匿性乳腺癌（OBC）的最佳治疗方法存在争议。治疗选择包括单纯乳房切除术（MAST）、单纯放射治疗（XRT）或乳房切除术加放射治疗（MXRT）。
方法
我们从 2004 年至 2014 年在国家癌症数据库中查询了接受 MAST、XRT 或 MXRT 治疗的 OBC 患者。我们利用倾向评分匹配进行了三项头对头比较。采用 Kaplan-Meier 分析比较总生存率（OS）。
结果
共有 190 例患者接受 XRT，237 例患者接受 MAST，244 例患者接受 MXRT。在 MXRT 与 XRT 比较中，5 年 OS 分别为 78.2%和 82.8%。在 MXRT 与 MAST 比较中，5 年 OS 分别为 81.5%和 86.7%。在 MAST 与 XRT 比较中，5 年 OS 分别为 83.2%和 82.5%。所有配对比较的 OS 均无差异。
结论
接受 MAST、XRT 或 MXRT 治疗的患者的 OS 无差异，提示隐匿性乳腺癌患者可考虑行保乳治疗。
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