Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110298. doi: 10.1016/j.msec.2019.110298. Epub 2019 Oct 13.
Cancer is a leading cause of mortality worldwide. Cell membrane-coated nanocarriers actively targeting tumor sites are known to circumvent the limitations of conventional treatments and nanosized drug delivery systems. Cell membrane-coated nanocarriers can evade the immune system and can target tumors, thereby exhibiting a prolonged circulation time, enhancing tumor accumulation, increasing cancer therapeutic efficacy, and facilitating tumor imaging in vivo. Numerous studies have focused on cell membrane-coated nanocarriers homing to tumors. The use of these biomimetic nanocarriers in combination with photothermal or photodynamic cancer therapy have received increasing attention. This review discusses various sources of cell membranes, which have been harnessed previously in this field and highlights the mechanism underlying the targeting action of these nanocarriers and the method of their extraction, along with the applications of biomimetic cell membrane-coated nanocarriers in cancer phototherapy and diagnosis. Finally, this review discusses prospects in methods to resist cancer metastasis.
癌症是全球主要的死亡原因。众所周知，细胞膜包覆的纳米载体能够主动靶向肿瘤部位，克服传统治疗方法和纳米药物递送系统的局限性。细胞膜包覆的纳米载体可以逃避免疫系统，并靶向肿瘤，从而表现出延长的循环时间、增强肿瘤积累、提高癌症治疗效果，并促进体内肿瘤成像。许多研究都集中在靶向肿瘤的细胞膜包覆的纳米载体上。这些仿生纳米载体与光热或光动力癌症治疗的结合使用受到了越来越多的关注。本综述讨论了先前在该领域中利用的各种细胞膜来源，并强调了这些纳米载体靶向作用的机制及其提取方法，以及仿生细胞膜包覆的纳米载体在癌症光疗和诊断中的应用。最后，本综述讨论了抵抗癌症转移的方法的前景。
