烟酰胺核苷酸转氢酶作为线粒体生物学的传感器。
Nicotinamide Nucleotide Transhydrogenase as a Sensor of Mitochondrial Biology.
机构信息
Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy.
Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy.
出版信息
Trends Cell Biol. 2020 Jan;30(1):1-3. doi: 10.1016/j.tcb.2019.11.001. Epub 2019 Nov 18.
The enzyme nicotinamide nucleotide transhydrogenase (NNT) transfers hydride from NADH to NADP coupled to H translocation across the inner mitochondrial membrane. In a recent study, Kampjut and Sazanov reveal that the bifunctional NNT mechanism rules the NAD(P)/NAD(P)H interconversion ratio, which in turn regulates antioxidant defense and sirtuin actions.
酶烟酰胺核苷酸转氢酶（NNT）将氢从 NADH 转移到 NADP，同时伴随着 H 穿过线粒体内膜的转运。在最近的一项研究中，Kampjut 和 Sazanov 揭示了双功能 NNT 机制控制 NAD(P)/NAD(P)H 的转化比例，而这反过来又调节了抗氧化防御和沉默调节蛋白的作用。
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