白细胞介素-18 在胰腺炎和胰腺癌中的作用。
The role of interleukin-18 in pancreatitis and pancreatic cancer.
机构信息
Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, Germany; Department of Hepatopancreatobiliary Surgery, The third Xiangya hospital, Central south university, Changsha 410013, Hunan, China.
Department of Hepatopancreatobiliary Surgery, The third Xiangya hospital, Central south university, Changsha 410013, Hunan, China.
出版信息
Cytokine Growth Factor Rev. 2019 Dec;50:1-12. doi: 10.1016/j.cytogfr.2019.11.001. Epub 2019 Nov 9.
Originally described as an interferon (IFN)-γ-inducing factor, interleukin (IL)-18 has been reported to be involved in Th1 and Th2 immune responses, as well as in activation of NK cells and macrophages. There is convincing evidence that IL-18 plays an important role in various pathologies (i.e. inflammatory diseases, cancer, chronic obstructive pulmonary disease, Crohn's disease and others). Recently, IL-18 has also been shown to execute specific effects in pancreatic diseases, including acute and chronic pancreatitis, as well as pancreatic cancer. The aim of this study was to give a profound review of recent data on the role of IL-18 and its potential as a therapeutic target in pancreatic diseases. The existing data on this topic are in part controversial and will be discussed in detail. Future studies should aim to confirm and clarify the role of IL-18 in pancreatic diseases and unravel their molecular mechanisms.
最初被描述为一种干扰素 (IFN)-γ诱导因子，白细胞介素 (IL)-18 已被报道参与 Th1 和 Th2 免疫反应，以及自然杀伤 (NK) 细胞和巨噬细胞的激活。有令人信服的证据表明，IL-18 在各种病理状态（即炎症性疾病、癌症、慢性阻塞性肺疾病、克罗恩病等）中发挥重要作用。最近，IL-18 也被证明在胰腺疾病中具有特定的作用，包括急性和慢性胰腺炎以及胰腺癌。本研究旨在对 IL-18 的作用及其作为胰腺疾病治疗靶点的潜力的最新数据进行深入综述。关于这一主题的现有数据在某种程度上存在争议，将详细讨论。未来的研究应旨在确认和阐明 IL-18 在胰腺疾病中的作用，并阐明其分子机制。
Zotero 插件