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酷似脑膜瘤的继发性弥漫性大B细胞淋巴瘤

Secondary Diffuse Large B-cell Lymphoma Mimicking Meningioma.

作者信息

Garcia-Grimshaw Miguel, Posadas-Pinto Diego, Delgado-de la Mora Jesus, Jimenez-Ruiz Amado

机构信息

Neurology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, MEX.

Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, MEX.

出版信息

Cureus. 2019 Oct 4;11(10):e5833. doi: 10.7759/cureus.5833.

Abstract

Meningiomas are the most common benign intracranial tumors accounting for up to 30% of non-glial tumors of the central nervous system (CNS); on neuroimaging studies, they usually appear as a lobular, extra-axial mass with well-circumscribed margins mostly located in the parasagittal aspect of the cerebral convexity. On magnetic resonance imaging (MRI) of the brain, meningiomas are typically isointense to hypointense relative to grey matter in the T1-weighted sequence and isointense to slight hyperintense relative to grey matter on the T2-weighted sequence with avid homogeneous enhancement after contrast administration. A thin linear enhancement along the dura infiltrating away from the lesion, known as the dural tail sign, was once thought to be a pathognomonic feature of meningiomas, but this non-specific sign can also be seen in other meningioma-like lesions. Several benign and malignant pathologies may mimic some of the neuroimaging characteristics of meningiomas; among them dural metastases of lymphomas. When approaching a patient with suspected meningioma, close attention to the neuroimaging features may help distinguish them from meningioma-like lesions. Here we present the case of a woman with CNS involvement of non-Hodgkin lymphoma that presented with a dural mass resembling the neuroimaging characteristics of a meningioma.

摘要

脑膜瘤是最常见的颅内良性肿瘤,占中枢神经系统(CNS)非胶质瘤的30%;在神经影像学研究中,它们通常表现为分叶状、轴外肿块,边界清晰,大多位于脑凸面矢状旁。在脑部磁共振成像(MRI)上,脑膜瘤在T1加权序列中相对于灰质通常呈等信号至低信号,在T2加权序列中相对于灰质呈等信号至轻度高信号,注射造影剂后呈明显均匀强化。沿硬脑膜远离病变处有薄的线性强化,称为硬脑膜尾征,曾被认为是脑膜瘤的特征性表现,但这种非特异性征象也可见于其他脑膜瘤样病变。几种良性和恶性病变可能模仿脑膜瘤的一些神经影像学特征;其中包括淋巴瘤的硬脑膜转移。当处理疑似脑膜瘤的患者时,密切关注神经影像学特征可能有助于将其与脑膜瘤样病变区分开来。在此,我们报告一例非霍奇金淋巴瘤累及中枢神经系统的女性病例,其表现为类似脑膜瘤神经影像学特征的硬脑膜肿块。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c1b/6827702/0a36e1e16a3f/cureus-0011-00000005833-i01.jpg

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